Department of Molecular, Cellular, and Developmental Biology
University of California, Santa Barbara
Santa Barbara, CA 93106
Email: wilson@lifesci.ucsb.edu

Project:             Advancing Marine Biotechnology: Use of OCS Oil Platforms as Sustainable Sources of Marine Natural Products

 

Education:          B.S.                    Pharmacy, Massachusetts College of Pharmacy & Allied Health                     1963

                             Sciences, Boston, MA                         

                             Ph.D.                  Pharmacology, School of Medicine, Tufts University, Boston, MA                   1967

 

Positions:          1995-Present       Professor of Biochemistry and Pharmacology, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA

            1978-1995          Professor of Biochemistry and Pharmacology, Division of Molecular, Cellular, and Developmental Biology, Department of Biological Sciences, University of  Santa Barbara, CA

                      1987-1991          Chair, Department of Biological Sciences, University of California, Santa Barbara, CA

                            1976-1978          Associate Professor, Department of Biological Sciences, University of California, Santa Barbara, CA

                            1969-1975           Assistant Professor, Department of Pharmacology, Stanford University School of Medicine, Stanford, CA

Selected Publications:

Jordan, M.A., Ojima, I., Rosas, F., Distefano, M., Wilson, L., Scambia, G., and C. Ferlini. 2002. Effects of novel taxanes SB-T-1213 and IDN5109 on tubulin polymerization and mitosis  Chem Biol 9(1): 93-101.

Newton, C.N., DeLuca, J.G., Himes, R.H., Miller, H.P., Jordan, M.A., and L. Wilson. 2002. Intrinsically slow dynamic instability of HeLa cell microtubules in vitro.  J. Biol. Chem. 277(45): 42456-42462.

Ojeda-Lopez, M.A., Jones, J., Miller, H., Wilson, L., Li, Y.L., and S. Cyrus. 2002. In vitro synchrotron x-ray studies of the structure of supramolecular assemblies of neuronal cytoskeletal protein fibers and associated proteins.  Biophys J.  82(1): 2025 Part 2.

Panda, D., Miller, H.P., and L. Wilson. 2002. Determination of the size and chemical nature of the stabilizing "cap" at microtubule ends using modulators of polymerization dynamics.  Biochemistry-US 41(5): 1609-1617.

DeLuca, J.G. and L. Wilson. 2001. Regulation of purified human kinesin.  Mol Biol Cell 12: 1702, Suppl. S.

DeLuca, J.G., Newton, C.N., Himes, R.H., Jordan, M.A., and L. Wilson. 2001. Purification and characterization of native conventional kinesin, HSET, and CENP-E from mitotic HeLa cells.  J. Biol. Chem. 276(30): 28014-28021.

Kamath, K., Goncalves, A., Braguer, D., Martello, L., Briand, G., Horwitz, S., Wilson, L., and M.A. Jordan. 2001. Studies in taxol-resistant cells indicate that microtubule dynamics must be regulated within a narrow range for successful mitosis.  Mol Biol Cell 12: 1735 Suppl. S.

Ngan, V.K., Bellman, K., Hill, B.T., Wilson, L., and M.A. Jordan. 2001. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic vinca alkaloids vinorelbine and its newer derivative, vinflunine.  Molec. Pharmacol. 60: 1-8.

Panda, D., Feinstein, S., and L. Wilson. 2001. Differential modulation of microtubule dynamics by 3-repeat and 4-repeat tau isoforms: Implications for neurodegenerative disease.  Mol. Biol. Cell 12: 938, Suppl. S.

Pfohl, T., Kim, J.H., Yasa, M., Miller, H.P., Wong, G.C.L., Bringezu, F., Wen, Z., Wilson, L., Kim, M.W., Li, Y., and C.R. Safinya. 2001. Controlled modification of microstructured silicon surfaces for confinement of biological macromolecules and liquid crystals.  Langmuir 17(17): 5343-5351.

Skoufias, D.A., Andreassen, P.R., Lacroix, F.B., Wilson, L., and R.M. Margolis. 2001. Mammalian Mad2 and Bub1/BubR1 recognize distinct spindle attachment and kinetochore tension checkpoints.  Proc. Nat. Acad. Sci. (USA) 98: 4492-4497.

Ngan, V.K., Bellman, K., Panda, D., Hill, B.T., Jordan, M.A., and L. Wilson. 2000. Novel Actions of the antitumor drugs vinflunine and vinorelbine on microtubules.  Cancer Res. 60: 5045-5051.

Panda, D., Ananthnarayan, V., Larson, G., Shih, C., Jordan, M.A., and L. Wilson. 2000. Interaction of the antitumor compound cryptophycin-52 with tubulin.  Biochemistry 39: 14121-14127.

Tsuchiya, E. and L. Wilson.  2000.  Dynamics of microtubules composed of mutated yeast beta-tubulins in living cells.  Mol Biol Cell 11: 985, Suppl. S.

Jordan, M. A. and L. Wilson. 1999. The use and action of drugs in analyzing mitosis.  In "Mitosis and Meiosis", Methods in Cell Biology 61: 267-295.

Margolis, R.L., and L. Wilson. 1998. Microtubule treadmilling: What goes around comes around. BioEssays 20: 830-836.

Wilson, L. 1998. Use of drugs to study the role of microtubule assembly dynamics in living cells. Methods in Enzymology 298: 252-276.

Panda, D., Himes, R. H., Moore, R. E., Wilson, L., and M.A. Jordan. 1997. Mechanism of action of the unusually potent mitotic inhibitor, cryptophycin 1. Biochemistry 36: 12948-12953.

Panda, D., Miller, H. P., Islam, K., and L. Wilson. 1997. Stabilization of microtubule dynamics by estramustine by binding to a novel site in tubulin: A possible mechanistic basis for its antitumor action. Proc. Natl. Acad. Sci. U.S.A. 94: 10560-10564.

Wilson, L. and M.A. Jordan. 1995. Microtubule dynamics: taking aim at a moving target. Chemistry and Biology 2: 569-573.

Davis, A., Sage, C. R., Wilson, L., and K.W. Farrell. 1993. Purification and biochemical characteriza-tion of tubulin from the budding yeast Saccharomyces cerevisiae. Biochemistry 32: 8823-8835.

Toso, R.J., Jordan, M A., Farrell, K.W., Matsumoto, B., and L. Wilson. 1993. Kinetic stabilization of microtubule dynamic instability in vitro by vinblastine. Biochemistry 32: 1285-1293.

Wendell, K.L., Wilson, L., and M.A. Jordan. 1993. Mitotic block in HeLa cells by vinblastine: ultrastructural changes in kinetochore-microtubule attachment and in centrosomes. J. Cell Sci 104: 261-274.

Jordan, M.A., Thrower, D., and L. Wilson. 1992. Effects of vinblastine, podophyllotoxin, and nocodazole on mitotic spindles: implications for the role of microtubule dynamics in mitosis. J. Cell Sci. 102:  401-416.

Skoufias, D. and L. Wilson. 1992. Mechanism of inhibition of microtubule polymerization by colchicine: inhibitory potencies of unliganded colchicine and tubulin-colchicine complexes. Biochemistry 31: 738-746.

Skoufias, D.A., Wilson, L., and W.D. Detrich III. 1992. The colchicine binding sites of brain tubulins from an Antarctic fish and from a mammal are functionally similar but not identical; implications for microtubule assembly at low temperature. Cell Motil & Cytosk. 21: 272-280.

Thrower, D., Jordan, M.A., and L. Wilson. 1991. Quantitation of cellular tubulin in microtubules and tubulin pools by a competetive ELISA. Journal of Immunological Methods 136: 45-51.

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