Department of Ecology, Evolution and Marine Biology
University of California
Santa Barbara, CA 93106
Email: rsjacobs@chem.ucsb.edu

Project:             Advancing Marine Biotechnology: Use of OCS Oil Platforms as Sustainable Sources of Marine Natural 

                                                         Products

 

Education:          B.S.                     Biology, Northwestern University, Evanston, IL                                                1964

                             Ph.D.                   Pharmacology, Stritch School of Medicine, Loyola University,

                                                          Chicago, IL                                                                                                       1971

 

Positions:          1995-Present      Professor of Pharmacology, Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, CA

            1982-1995            Professor of Pharmacology, Department of Biological Sciences, University of California, Santa Barbara, CA

                      1978-1982            Associate Professor of Pharmacology, Department of Biological Sciences, University of California, Santa Barbara, CA

                      1974-1978            Assistant Professor of Pharmacology, Department of Biological Sciences, University of California, Santa Barbara, CA

                      1971-1974            Assistant Professor of Pharmacology, Department of Pharmacology, Stritch School of Medicine, Loyola University, Chicago, IL

Selected Publications:

Stevenson, C.S., Capper, E.A., Roshak, A.K., Marquez, B., Eichman, C., Jackson, J.R., Mattern, M., Gerwick, W.H., Jacobs, R.S., and L.A. Marshall. 2002. The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore. J Pharmacol Exp Ther 303(2): 858-866.

Stevenson, C.S., Capper, E.A., Roshak, A.K., Marquez, B., Grace, K., Gerwick, W.H., Jacobs, R.S., and L.A. Marshall. 2002. Scytonemin - a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases. Inflamm Res 51(2): 112-114.

Bemis, D.L., Roussis, V., Vagias, C., and R.S. Jacobs. 2000. Chloroplast fatty acid composition in Mediterranean populations of the marine Chlorophyte, Anadyomene stellata. Z Naturforsch C 55(7-8): 569-575.

MacPherson, J.C. and R.S. Jacobs. 2000. An 18.5 kDa protein from the amebocyte of Limulus polyphemus, homologous to the previously described amebocyte aggregation factor, expresses alternative phospholipase A(2) activity. Comp Biochem Phys B 127(1): 31-44.

Mayer, A.M.S., Fenical, W., and R.S. Jacobs. 2000. The marine pseudopterosins modulate rat microglia superoxide and thromboxane generation. FASEB J 14(8): 266.

Mayer, A.M.S., Oh, S., Fenical, W., and R.S. Jacobs.  1999. Escherichia coli LPS-primed rat brain microglia superoxide and thromboxane B-2 generation is inhibited by the marine pseudopterosins. Shock 11: 58 Suppl. 1.

Pennings, S.C., Paul, V.J., Dunbar, D.C., Hamann, M.T., Lumbang, W.A., Novack, B., and R.S. Jacobs. 1999. Unpalatable compounds in the marine gastropod Dolabella auricularia: Distribution and effect of diet. J Chem Ecol 25(4): 735-755.

Qureshi, A., Stevenson, C.S., Albert, C.L., Jacobs, R.S., and D.J. Faulkner. 1999. Homo- and nor-plakotenin, new carboxylic acids from the Palauan sponge Plakortis lita.  J Nat Prod 62(8): 1205-1207 Aug 1999.

MacPherson, J.C., Pavlovich, J.G., and R.S. Jacobs. 1998. Phospholipid composition of the granular amebocyte from the horseshoe crab, Limulus polyphemus. Lipids 33(9): 931-940.

Mayer, A.M.S., Jacobson, P.B., Fenical, W., Jacobs, R.S., and K.B. Glaser. 1998. Pharmacological characterization of the pseudopterosins: Novel anti-inflammatory natural products isolated from the caribbean soft coral, Pseudopterogorgia elisabethae. Life Sciences 62(26): 401-7.

Wylie, B.L., Ernst, N.B., Grace, K.J., and R.S. Jacobs. 1997. Marine natural products as phospholipase A₂ inhibitors. In: Progress in Surgery, Eds. W. Uhl, T.J. Nevalainen, and M.W. Büchler. Basel, Karger. 24:146-152.

MacPherson, J.C., Pavlovich, J.G., and R.S. Jacobs. 1996. Biosynthesis of arachidonic acid metabolites in Limulus polyphemus amebocytes: Analysis by liquid chromatography-electrospray ionization mass spectrometry. Biochim. Biophys. Acta. 1303(2): 127-36.

Michailova, M.V., Bemis, D.L., Wise, M.L., Gerwick, W.H., Norris, J.N., and R.S. Jacobs. 1995. Structure and synthesis of novel conjugated polene fatty acids from the marine green alga, Anadyomene stellate. Lipids 30: 583-589.

Grace, K.J.S., Zavortink, D., and R.S. Jacobs. 1994. Inactivation of bee venom phospholipase A₂ by a sesquiterpene furanoic acid marine natural product. Biochem. Pharm. 47: 1427-1434.

Marshall, L.A., Winkler, J.D., Griswold, D.E., Bolognese, B., Roshak, A., Sung, S.M., Webb, E.F., and R.S. Jacobs. 1994. Effects of scaradial, a type II phospholipase A₂ inhibitor on human neutrophil arachidonic acid mobilization and lipid media for formation. J. Pharm. Exp. Ther. 268: 709-717.

Jacobs, R.S., Bober, M.A., Pinto, I., Williams, A.B., Jacobson, P.B., and M.S. de Carvalho. 1993. Pharmacological studies of marine novel marine metabolites. In: Advances of Marine Biotechnology, Vol. 1, Plenum, NY, p. 77-99.

Mayer, A.M.S., Paul, V.J., Fenical, W., Norris, J.N., de Carvalho, M.S., and R.S. Jacobs. 1993. Phospholipase A₂ inhibitors from marine algae. Hydrobiologia 260(1):1-9.

Williams, A.B. and R.S. Jacobs. 1993. A marine natural product, Patellamide D, reverses multidrug resistance in a human leukemic cell line. Cancer Letters 71: 97-102.

Potts, B.C.M., Faulkner, D.J., and R.S. Jacobs. 1992. Phospholipase A₂ inhibitors from marine organisms. J. Natural Products 55: 1701-1717.

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